'Natural step'
The Skype option will be added to MySpace's existing instant messaging feature, and will not require MySpace users to download any additional Skype software.
"Internet calling is the natural next step for how our members communicate with each other," said MySpace chief executive Chris DeWolfe.
No financial terms of the arrangement have been released.
MySpace has more than 110 million users, while Skype has 220 million.
